Corrositex-In Vitro Dermal Corrosivity Test-MB Research Labs

<body> <p align="center">This page uses frames, but your browser doesn't support them. <br> For information about Corrositex and MB Research Labs, please see: <a href="http://www.mbresearch.com">www.mbresearch.com</a></p> <TABLE height=580 cellSpacing=0 cellPadding=0 width="90%" border=0> <TBODY> <TR> <TD width="100%" bgColor=#ffffce height=85><IMG height=75 src="../CORROSITEX-BANNER-ANIMATED.gif" width=500 align=right border=0><A name=top></A></TD> </TR> <TR> <TD width="100%" height=115><DIV align=center> <CENTER> <TABLE cellSpacing=0 cellPadding=0 width="90%" border=0> <TBODY> <TR> <TD width="100%"><P align=center><B><FONT size=4>MB Research Laboratories performs the Corrositex test as a <U>featured assay</U>.  For more information about MB Research and our other in vitro and alternative toxicology tests, see:  <A href="http://www.mbresearch.com" target=_blank>www.mbresearch.com</A>.</FONT></B> <P align=center></P></TD> </TR> </TBODY> </TABLE> </CENTER> </DIV> <DIV align=center> <TABLE height=1707 cellSpacing=0 cellPadding=0 width="80%" border=0> <TBODY> <TR> <TD width="100%" height=144><H2><FONT size=4><A name=What>What</A> is <STRONG>Corrositex</STRONG>?</FONT></H2> <P align=left><B>Corrositex</B> is an <I>in vitro</I> method used to determine the dermal corrosive potential of chemicals and chemical mixtures.</P> <P align=left><B>Corrositex </B>has been designed as a  replacement for the dermal corrosivity rabbit test based upon proprietary biomembrane and chemical detection technology developed by<BR>  <A href="http://www.invitrointl.com" target=_blank>In Vitro International</A>.   </P> <P align=center></P></TD> </TR> <TR> <TD width="100%" height=204><H2 align=left><FONT size=4><A name=Why>Why</A> Use <STRONG>Corrositex</STRONG>?</FONT></H2> <CENTER> <TABLE cellSpacing=0 cellPadding=0 width="75%" border=0> <TBODY> <TR> <TD align=middle width="19%" height=100><IMG height=48 src="../time-button.jpg" width=50 border=0></TD> <TD width="81%" height=100><STRONG>Time Savings</STRONG>: Corrositex testing can provide a Packing Group determination in a matter of minutes and no more than 4 hours, unlike animal testing which can take 2 - 4 weeks.</TD> </TR> <TR> <TD align=middle width="19%" height=100><IMG height=48 src="../accuracy-button.jpg" width=50 border=0></TD> <TD width="81%" height=100><B>Accuracy:</B>  More accurate than pH testing and is packing group specific.</TD> </TR> <TR> <TD align=middle width="19%" height=100><IMG height=48 src="../saving-cost.jpg" width=50 border=0></TD> <TD width="81%" height=100><STRONG>Cost Savings</STRONG>: Reduced shipping charges, additional cost savings workplace safety and MSDS development.</TD> </TR> </TBODY> </TABLE> </CENTER> <CENTER> <CENTER> <P align=center><A href="#top"><IMG height=20 src="../backtotop.jpg" width=118 border=0></A></P> </CENTER> </CENTER></TD> </TR> <TR> <TD width="100%" height=291><B><FONT size=4><A name=How>How</A> the Test Works</FONT></B> <BR> <TABLE cellSpacing=0 cellPadding=0 width="100%" border=0> <TBODY> <TR> <TD width="100%"><B>Corrositex</B> is a non-animal alternative toxicology test. Although not a classical "<I>in vitro</I>" test, <B>Corrositex</B> uses a synthetic membrane-based detection system to determine the UN packing group classification of chemicals, consumer products or other hazardous materials. The results, expressed as a break-through time, correlate well with rabbit dermal corrosivity tests. <P>In the <B>Corrositex </B>testing system, a glass vial filled with a chemical detection fluid is capped by a<I> </I>proprietary bio-barrier membrane, which is designed to mimic the effect of corrosives on living skin.<BR> <BR> <B>Corrositex </B>measures the time required for a test article to pass through a hydrated collagen matrix and supporting filter membrane.  As the corrosive sample passes through or destroys this bio-barrier, the underlying liquid Chemical Detection System changes color or texture. The time it takes for the sample to break through the membrane is recorded and compared to a classification chart to determine corrosivity/noncorrosivity for assignment of the proper U.N. Packing Group classification for U.S. DOT or EPA compliance.</P> <P></P></TD> </TR> <TR> <TD width="100%"><DIV align=center> <TABLE height=126 cellSpacing=0 cellPadding=0 width="66%" bgColor=#ffffff border=0> <TBODY> <TR> <TD align=right width="105%" height=33><P align=right><B>Biobarrier Disc<BR> </B><I>Proprietary Bio-membrane </I></P></TD> <TD width="25%" height=124 rowSpan=2><P align=center><IMG height=180 src="../corrositex-vial.jpg" width=100 align=right border=0></P></TD> </TR> <TR> <TD align=right width="105%" height=89><P align=right><B>Chemical Detection Fluid </B></P></TD> </TR> </TBODY> </TABLE> </DIV></TD> </TR> </TBODY> </TABLE> <CENTER> <CENTER> <P align=center><A href="#top"><IMG height=20 src="../backtotop.jpg" width=118 border=0></A> </P> </CENTER> </CENTER></TD> </TR> <TR> <TD width="100%" height=918><B><FONT size=4><A name=Regulatory>Regulatory</A> Acceptance</FONT></B><BR> <BR> The following regulatory agencies accept <B>Corrositex</B>. <BR> <BR> <B>Department of Transportation - DOT-E 10904</B> <BR> Original exemption granted April 28, 1993 <BR> Renewals granted: <BR> March 22, 1995 <BR> November 30, 1997 <BR> January 12, 1999 <BR> December 12, 2000 <BR> September 20, 2002 <BR> July 19, 2004  <P><BR> <B>Consumer Product Safety Commission (CPSC) </B><BR> Formal Acceptance, NIEHS press release dated 3/21/00 <BR> <BR> <B>European Centre for the Validation of Alternative Methods (ECVAM)<BR> </B>12/2002 <BR> <BR> <B>EPA Federal Register / Vol. 60, No. 142 Dermal Corrosion</B> <BR> Method 1120 June 13, 1997 <BR> Formal Acceptance, NIEHS press release dated 3/21/00 <BR> <BR> <B>Food & Drug Administration (FDA) </B><BR> Formal Acceptance, NIEHS press release dated 3/21/00<BR> <BR> <B>International Air Transportation Association (IATA) </B><BR> Letter of acceptance dated December 17, 1993 <BR> <BR> <B>National Institute of Environmental Health Sciences (NIEHS) </B><BR> Endorsement dated 6/22/99 <BR> <BR> <B>Occupational Safety and Health Administration (OSHA) </B><BR> Letter of Interpretation dated March 3, 1994 <BR> Formal Acceptance, NIEHS press release dated 3/21/00 <BR> <BR> <B>Transport Canada - Permit For Equivalent Level of Safety SU 4483 </B><BR> Original approval 8/14/96 <BR> Additional renewal 9/18/98 <BR> Additional renewal 1/15/01 <BR> Full Draize Replacement Acceptance 3/5/02  </P> <P align=center><BR> <A href="#top"><IMG height=20 src="../backtotop.jpg" width=118 border=0></A></P></TD> </TR> <TR> <TD width="100%" height=150> <B>MB Research</B> is an authorized <B>Corrositex testing laboratory</B>. <P>For more information you may want to check out this link: <A href="http://www.invitrointl.com/corrositex/index_files/frame.htm" target=_blank>Corrositex info<BR> </A><BR> For Searching Corrositex Assay Test Results, you may purchase results from the <A href="http://www.invitrointl.com/store/" target=_blank>Corrositex Database</A> provided by Invitro International. <P>More information about Corrositex can be found at the following websites: <P align=center><FONT size=3><A href="http://iccvam.niehs.nih.gov/methods/corrode.htm" target=_blank>The Interagency Coordinating Committee on the Validation of <BR> Alternative Methods (ICCVAM)</A><BR> </FONT><BR> <A href="http://iccvam.niehs.nih.gov/methods/corrode.htm" target=_blank>Dermal Corrosivity and Irritation Working Group (DCIWG)</A> <P align=center><A href="http://iccvam.niehs.nih.gov/methods/corrdocs/sampprot.pdf" target=_blank>ICCVAM Sample Protocol</A> <P></P></TD> </TR> </TBODY> </TABLE> </DIV></TD> </TR> <TR> <TD width="100%" height=21>MB Research began utilizing Corrositex in 1996 and has since developed and validated more alternative and in vitro toxicology assays. <P></P></TD> </TR> <TR> <TD width="100%" height=21><P align=center><STRONG><FONT face="Times New Roman"><A href="http://www.mbresearch.com" target=_blank><IMG height=48 src="../Graphics/MB_Logo-Black-Small.jpg" width=275 border=0><BR> </A></FONT></STRONG><SMALL><SMALL>CORROSITEX<SUP>®</SUP> is a registered trademark and is used with the permission of In Vitro International, Inc.</SMALL></SMALL></P> <P align=center><BR> <A href="#top"><IMG height=20 src="../backtotop.jpg" width=118 border=0></A></P></TD> </TR> <TR> <TD width="100%" bgColor=#ffffce height=21><P align=center></P></TD> </TR> </TBODY> </TABLE> <p> </p> </body>