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OCSPP Series 870 - EPA Regulatory Testing Services

MB specializes in the conduct of Good Laboratory Practice (GLP) compliant toxicology assays. MB Research studies are designed to meet the requirements of the applicable regulatory agencies, or tailored to meet your specific needs.

MB Research offers more than 40 years experience in the conduct of acute, sub-chronic and chronic toxicology designed to meet the Office of Chemical Safety and Pollution Prevention (OCSPP) regulatory guidelines.

OCSPP Series 870 (OCSPP Harmonized Guidelines)*

*Formerly known as OPPTS.

Table of EPA Toxicity Categories

Study Category I Category II Category III Category IV
Acute Oral Up to and including 50 mg/kg >50 through 500 mg/kg >500 through 5000 mg/kg >5000 mg/kg
Acute Dermal Up to and including 200 mg/kg >200 through 2000 mg/kg >2000 through 5000 mg/kg >5000 mg/kg
Acute Inhalation Up to and including 0.05 mg/liter >0.05 through 0.5 mg/liter >0.5 through 2 mg/liter >2 mg/liter
Eye Irritation Corrosive (irreversible destruction of ocular tissue) or corneal involvement or irritation persisting for more than 21 days Corneal involvement or irritation clearing in 8-21 days Corneal involvement or irritation clearing in 7 days or less Minimal effects clearing in less than 24 hours
Skin Irritation Corrosive (tissue destruction into the dermis and/or scarring) Severe irritation at 72 hours (severe erythema or edema) Moderate irritation at 72 hours (moderate erythema) Mild or slight irritation (no irritation or slight erythema)
Study Study Results Study Results
Dermal Sensitization Product is a sensitizer or is positive for sensitization Product is not a sensitizer or is negative for sensitization
Taken from EPA

Acute Toxicity Guidelines

(Background) EPA Health Effects Test Guidelines 870.1000

The toxicological evaluation of a substance following short term exposure is integral to the EPA in the assessment of a chemical that falls under it's pesticide and toxic substances programs.

The published guideline is intended to meet regulatory testing requirements of both the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) (7 U.S.C. 136, et seq.) and the Toxic Substances Control Act (TSCA) (15 U.S.C. 2601).

Source: OPPTS 870.1000 Acute Toxicity Testing—Background, dated August 1998.

Below are links to the EPA OCSPP guidelines to test methods performed at MB Research.

Subchronic Toxicity Guidelines

Genetic Toxicity Guidelines

** Link to pdf

Other In Vivo Capabilities

  • Pharmacology
  • In Vivo Efficacy
  • Toxicokinetics / Pharmacokinetics
  • Neurotoxicity Screen Studies (Functional Observational Battery)
  • Mouse Ear Swelling Test
  • Oral Mucosal Irritation (Hamster, Rat)
  • Oral Tissue Corrosivity (Rat)
  • Vaginal & Anal Mucous Membrane Irritation (Rabbit)
  • Medical Device Testing – Subcutaneous Implant
  • Intra-vaginal Irritation (Rabbit)
  • Penile Irritation (Rabbit)
  • Comedogenicity Assay (Rabbit)
  • Photo-Sensitization (Rabbit, Mouse – Photo-LLNA)
  • Photo-Toxic Irritation (Rabbit, Mouse)
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